|
KMID : 0360220100510081047
|
|
Journal of the Korean Ophthalmological Society
2010 Volume.51 No. 8 p.1047 ~ p.1053
|
|
|
Clinical Effects of Combination Therapy Using Heparin and Phospholipid in Severe Dry Eye Syndrome
|
|
Joo Kwang-Sic
Chun Yeoun-Sook
Kim Jae-Chan
|
|
|
Abstract
|
|
|
Purpose: To evaluate the therapeutic effects of topical heparin (Hylo-Parinⓡ, Ursapharm Saarbr cken, Germany) and spray type phospholipids (Tears Againⓡ, Optima Pharmazeutische GmbH. Freising, Germany) in severe dry eye syndrome resistant to conventional therapy.
Methods: Twenty eyes of ten patients with refractory severe dry eye were treated with Hylo-Parinⓡ (two times a day) and Tears Againⓡ (three times a day) for three months. Before and one and three months after treatment, a symptom questionnaire was administered to the patients. The ocular surface disease index (OSDI), tear film break-up time, Schirmer test, conjunctival fluorescein staining examinations and filamentary keratitis were evaluated.
Results: After using Tears Againⓡ and Hylo-Parinⓡ, the OSDI score improved from 64.13 ± 15.12 to 43.80 ± 15.87 (p＜0.01). Tear film break-up time significantly increased from 1.0 ± 0.65 to 2.3 ± 0.73 seconds (p＜0.01) and conjunctival staining score (Oxford scale) significantly decreased from 3.85 ± 0.75 to 3.25 ± 0.97 (p＜0.01). Filamentary keratitis in the slit-lamp examination showed significant improvement (p＜0.01).
Conclusions: Tears Againⓡ and Hylo-Parinⓡ are considered as new treatment modalities for severe dry eye syndrome and filamentary keratitis in patients with chronic ocular surface disease resistant to conventional therapy. These treatments require additional research. J Korean Ophthalmol Soc 2010;51(8):1047-1053
|
|
|
KEYWORD
|
|
|
Dry eye, Filamentary keratitis, Heparin, Liposome, Phospholipid
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|